Table 1.
Patient and disease characteristics associated with mutation status. WT: wild type; F: female; M: male; ECOG PS: ECOG performance status; *: significant p-values (p ≤ 0.05).
| Characteristics | Total n (%) | EGFR Mutant n (%) | KRAS Mutant n (%) | EGFR and KRAS WT n (%) | p-Value |
|---|---|---|---|---|---|
| Overall n (%) | 142 (100.00) | 16 (11.27) | 47 (33.10) | 79 (55.63) | |
| Patients’ Characteristics | |||||
| Median age (years) | 62 (31–88) | 62 (45–87) | 60 (37–76) | 63 (31–88) | 0.338 |
| Sex F/M | 48/94 | 7/9 | 16/31 | 25/54 | 0.46 |
| Ethnicity | 0.006 * | ||||
| Caucasian | 140 (98.59) | 16 (100.00) | 47 (100.00) | 77 (97.47) | |
| Asian | 2 (1.41) | 0 (0.00) | 0 (0.00) | 2 (2.53) | |
| Smoking history | |||||
| Smoker | 108 (76.06) | 7 (43.75) | 42 (89.36) | 59 (74.68) | <0.001 * |
| Non-smoker | 31 (21.83) | 9 (56.25) | 3 (6.38) | 19 (24.05) | |
| ECOG PS | |||||
| 0–1 | 123 (86.62) | 14 (87.50) | 37 (78.72) | 72 (91.14) | 0.131 |
| ≥2 | 19 (13.38) | 2 (12.50) | 10 (21.28) | 7 (8.86) | |
| Disease Characteristics | |||||
| Pathology | |||||
| Adenocarcinoma | 127 (89.44) | 14 (87.50) | 46 (97.87) | 67 (84.81) | 0.050 * |
| Other | 15 (10.56) | 2 (12.50) | 1 (2.13) | 12 (15.19) | |
| Number of metastases | |||||
| 1 | 90 (63.38) | 10 (62.50) | 27 (57.45) | 53 (67.09) | 0.553 |
| ≥2 | 52 (36.62) | 6 (37.50) | 20 (42.55) | 26 (32.91) | |