Table 1.

Management of extra-cutaneous complications of toxic epidermal necrolysis.

System	Short Term Complications	Daily Specialist Review during Admission	Management	Long Term Complications
Ocular	Ocular surface damage, infection	Yes	Topical lubricant (non-preserved hyaluronate), corticosteroid drops (non-preserved dexamethasone 0.1%), topical antibiotic prophylaxis (moxifloxacin)	Corneal and conjunctival ulceration and scarring, dry eye, entropion, visual impairment, blindness
Oral	Infection, pain	Yes	White soft paraffin ointment to oral mucosa, warm saline mouthwashes, corticosteroid mouthwash (betamethasone sodium phosphate), antiseptic mouth rinse	Scarring may cause food trapping, limitation of oral mobility
Urogenital	Infection, erosions, pain	Yes	White soft paraffin ointment to the urogenital skin, potent topical corticosteroid ointment, silicone dressing to eroded surfaces	Adhesions: vaginal introital, dyspareunia, scarring, pigment changes
Respiratory	Hypoxia, airway compromise, infection, bronchial erosions	Intensive Care Unit (ICU) or High Dependency Unit (HDU) admission	Fibre optic bronchoscopy, ICU or HDU monitoring	Bronchiolitis obliterans causing severe airway obstruction