Table 4.
Genotype distribution of common CELA3A and CELA3B variants. Results were analyzed assuming dominant (shown in italics) or recessive models of inheritance. OR, odds ratio; CI, confidence interval.
| CELA3A | Nucleotide Change | Genotype | Patients | Controls | OR | p Value | 95% CI |
| Intron 6 | c.643-78T>C | TT | 153/225 (68%) | 186/295 (63%) | – | – | – |
| TC | 63/225 (28%) | 94/295 (31.9%) | 0.80 | 0.25 | 0.56–1.16 | ||
| CC | 9/225 (4%) | 15/295 (5.1%) | 0.78 | 0.56 | 0.33–1.81 | ||
| Exon 7 | c.750C > T | CC | 132/225 (58.7%) | 158/295 (53.5%) | – | – | – |
| CT | 81/225 (36%) | 117/295 (39.7%) | 0.81 | 0.25 | 0.57–1.15 | ||
| TT | 12/225 (5.3%) | 20/295 (6.8%) | 0.77 | 0.5 | 0.37–1.62 | ||
| Exon 7 | c.753G > A | GG | 132/225 (58.7%) | 158/295 (53.5%) | – | – | – |
| GA | 81/225 (36%) | 117/295 (39.7%) | 0.81 | 0.25 | 0.57–1.15 | ||
| AA | 12/225 (5.3%) | 20/295 (6.8%) | 0.77 | 0.5 | 0.37–1.62 | ||
| Intron 7 | c.795+21C>A | CC | 17/225 (7.6%) | 32/295 (10.8%) | – | – | – |
| CA | 95/225 (42.2%) | 127/295 (43.1%) | 1.49 | 0.21 | 0.80–2.76 | ||
| AA | 113/225 (50.2%) | 136/295 (46.1%) | 1.18 | 0.35 | 0.83–1.67 | ||
| CELA3B | Nucleotide Change | Genotype | Patients | Controls | OR | p Value | 95% CI |
| Intron 6 | c.643-7G>T | GG | 159/225 (70.6%) | 185/293 (63.1%) | – | – | – |
| GT | 60/225 (26.7%) | 91/293 (31.1%) | 0.71 | 0.07 | 0.49–1.03 | ||
| TT | 6/225 (2.7%) | 17/293 (5.8%) | 0.44 | 0.09 | 0.17–1.15 | ||
| Exon 7 | c.780T>C | TT | 1/225 (0.5%) | 0/293 (0%) | – | – | – |
| TC | 3/225 (1.3%) | 6/293 (2%) | – | – | – | ||
| CC | 221/225 (98.2%) | 287/293 (98%) | 1.15 | 0.83 | 0.32–4.14 | ||
| Intron 7 | c.795+21C>A | CC | 10/225 (4.4%) | 24/293 (8.2%) | – | – | – |
| CA | 90/225 (40%) | 125/293 (42.7%) | 1.92 | 0.09 | 0.90–4.1 | ||
| AA | 125/225 (55.6%) | 144/293 (49.1%) | 1.29 | 0.15 | 0.91–1.8 |