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. 2016 Dec 20;17(12):2149. doi: 10.3390/ijms17122149

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of BRAF^V600E in induced tumors led to tumor outgrowth inhibition. Melanomas were induced by 4-hydroxytamoxifen application on the flank of 4–10-week-old C57BL/6J Tyr::CreER^T2;Pten^LoxP/LoxP;Braf^CA/+ mice or DNA tattoo administration of the pVAX1/mTyr-Cre construct on the flank of Pten^LoxP/LoxP;Braf^CA/+ mice (n = 5 per group). When the average tumor size was 25 mm², tumor-bearing mice were placed on PLX4720 chow. Tumor outgrowth was monitored over time by digital photography, and tumor size was plotted against time from tumor induction for PLX4720-treated and control chow mock-treated animals. Data are expressed as the means ± SD.