Table 1.
Effect of mutual prodrugs (5a–c) in carrageenan induced edema (mm) in mice.
| Serial. No. | Inflammation at 0 h (mm) | Inflammation at 1 h (mm) | Inflammation at 2 h (mm) | Inflammation at 3 h (mm) | Inflammation at 4 h (mm) |
|---|---|---|---|---|---|
| Dose | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM |
| Control 10 mg/kg | 4.17 ± 0.08 | 4.40 ± 0.10 | 4.6 ± 0.06 | 4.85 ± 0.06 | 5.07 ± 0.06 |
| Dexibuprofen 20 mg/kg | 4.37 ± 0.06 | 4.35 ± 0.06 ns (1.1%) | 4.07 ± 0.02 *** (11.71%) | 3.90 ± 0.04 *** (19.58%) | 3.75 ± 0.06 *** (26.03%) |
| 5a 20 mg/kg | 4.42 ± 0.05 | 4.50 ± 0.04 ns (−2.27%) | 4.25 ± 0.06 ** (7.80%) | 4.12 ± 0.06 *** (15.05%) | 3.92 ± 0.02 *** (22.68%) |
| 5b 20 mg/kg | 4.37 ± 0.04 | 4.22 ± 0.1 ns (4.09%) | 4.25 ± 0.06 ** (7.80%) | 4.15 ± 0.02 *** (14.43%) | 3.92 ± 0.05 *** (22.68%) |
| 5c 20 mg/kg | 4.32 ± 0.04 | 4.22 ± 0.04 ns (4.09%) | 4.05 ± 0.02 *** (12.14%) | 3.80 ± 0.04 *** (21.64%) | 3.60 ± 0.04 *** (28.99%) |
Results are expressed as means ± SEM. Significant at, ** = p < 0.01, *** = p < 0.001, ns = non-significant when compared to control. Values in bracket indicate percent inhibition.