Table 6.

Docking results of pro-drug compounds using AutoDockVina.

Prodrugs	Docking Energy (kcal/mol)	Binding Pocket Residues
5a	−8.90	Gln189, His193, Lys197, Leu377, Phe390, Val281, Leu280, val273, Glu276, Gln275, His
5b	−9.90	Gln189, His193, Thr192, Ala188, Phe186, Tyr371, Trp373, His374, Leu276, Leu377, Ala429, Val430,Val433, Phe390, Leu394, Val281, Leu280
5c	−9.40	His193, Thr192, Ala188, Phe185, Val277, Lys197, Thr198, His372, Tyr371, His374, Leu377, Ala185
Dexibuprofen	−8.60	Gln189, Phe390, Val281, Leu263, Leu394 and Leu377