Figure 1.

Schematic representation of changes in the expression of genes regulating glucose metabolism, fatty acid metabolism, and insulin signaling in the kidneys of offspring exposed to maternal HF diet. Solid lines with arrowheads indicate known signaling events and interactions between glucose metabolism, fatty acid metabolism, and insulin signaling. Dashed lines with arrowheads denote proposed mechanisms contributing to maternal HF consumption-induced programmed hypertension. Solid square boxes indicate DEGs identified by next-generation sequencing (NGS).