Table 2.
Changes in the expression of shared differential expressed genes (DEGs) associated with fructose metabolism in the kidneys, brain, and heart of offspring exposed to maternal HF diet at 1 day of age.
| Gene ID | Symbol | Kidney | Brain | Heart |
|---|---|---|---|---|
| Fructose and mannose metabolism | ||||
| ENSRNOG00000001214 | Pfkl | 2.3 | 1.5 | 2.2 |
| ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
| ENSRNOG00000018911 | Pfkfb3 | 1.8 | ND | 4.5 |
| Adipocytokine signaling pathway | ||||
| ENSRNOG00000002946 | Socs3 | 1.6 | 0.5 | 3.9 |
| ENSRNOG00000007390 | Nfkbia | 1.9 | 1.9 | 3.5 |
| ENSRNOG00000004473 | Ppargc1a | 2.3 | 1.6 | 2.7 |
| ENSRNOG00000007284 | Slc2a1 | 3.0 | 2.3 | ND |
| ENSRNOG00000023509 | Irs2 | 2.1 | ND | 1.6 |
| Glycolysis/Gluconeogenesis | ||||
| ENSRNOG00000001214 | Pfkl | 2.3 | 1.5 | 2.2 |
| ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
| ENSRNOG00000013009 | Ldha | 2.2 | ND | 1.6 |
| Fatty acid metabolism | ||||
| ENSRNOG00000020624 | Acadsb | 1.9 | 2.0 | ND |
| Insulin signaling pathway | ||||
| ENSRNOG00000002946 | Socs3 | 1.6 | 0.5 | 3.9 |
| ENSRNOG00000004473 | Ppargc1a | 2.3 | 1.6 | 2.7 |
| ENSRNOG00000006388 | Pygl | 1.9 | ND | 3.2 |
| ENSRNOG00000006116 | Hk2 | 1.8 | ND | 2.1 |
| ENSRNOG00000023509 | Irs2 | 2.1 | ND | 1.6 |
| ENSRNOG00000003463 | Srebf1 | 2.1 | ND | 1.6 |
| ENSRNOG00000013397 | Foxo1 | 1.8 | ND | 2.2 |
Gene expression was quantified as reads per kilobase of exon per million mapped reads (RPKM). Genes that changed by RPKM of >0.3 and ≥2-fold differences between HF vs. control. Significant results are highlighted in bold. ND, not detectable.