Table 3.
Determinants of maternal plasma B vitamin status in pregnancy week 18 by multiple linear regression, n = 2797.
| Plasma Folate, nmol/L | Plasma Cobalamin, pmol/L | Plasma PLP, nmol/L | Plasma Riboflavin, nmol/L | Plasma tHcy, µmol/L | Plasma MMA, µmol/L | Plasma HK/XA | B Vitamin Score a | |
|---|---|---|---|---|---|---|---|---|
| B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | B (95% CI) | |
| Pre-pregnancy BMI c | −0.59 ** (−0.98, −0.20) | −16.7 ** (−22.0, −11.4) | −2.55 ** (−3.72, −1.38) | −0.60 (−1.25, 0.06) | −0.02 (−0.16, 0.12) | −0.006 ** (−0.008, −0.003) | 0.11 * (0.04, 0.18) | −0.47 ** (−0.60, −0.35) |
| Parity e | −1.33 ** (−1.72, −0.95) | −3.6 (−8.8, 1.6) | −1.28 * (−2.43, −0.12) | −1.08 * (−1.73, −0.43) | −0.01 (−0.15, 0.13) | −0.001 (−0.004, 0.002) | −0.03 (−0.09, 0.04) | −0.34 ** (−0.47, −0.22) |
| Age d | 2.69 ** (2.05, 3.32) | 12.3 * (3.6, 20.9) | 1.96 * (0.06, 3.86) | 0.30 (−0.77, 1.36) | 0.04 (−0.19, 0.27) | 0.002 (−0.002, 0.007) | −0.12 * (−0.24, −0.01) | 0.63 ** (0.43, 0.83) |
| Use of supplements b | 5.14 ** (4.35, 5.94) | 13.0 * (2.3, 23.7) | 8.49 ** (6.12, 10.85) | 1.80 * (0.48, 3.13) | −0.75 ** (−1.03, −0.47) | 0.001 (−0.004, 0.007) | −0.21 * (−0.35, −0.07) | 1.73 ** (1.48, 1.98) |
| Neopterin f | −0.12 (−0.35, 0.11) | −1.9 (−5.0, 1.2) | −1.00 * (−1.68, −0.31) | −0.08 (−0.47, 0.30) | 0.10 * (0.02, 0.18) | 0.003 ** (0.001, 0.004) | 0.19 ** (0.15, 0.23) | −0.12 ** (−0.20, −0.05) |
All variables were included in the model; a B vitamin score; added quintiles of folate, cobalamin, PLP and riboflavin; b No use versus use of supplements any time from four weeks before pregnancy up to pregnancy week 18; c Pre-pregnancy BMI, categorized; <18.5, 18.5-24.9, 25.0-29.9, 30.0-34.9, ≥35.0; d Age, categorized; <25 years, 25–35 years, >35 years; e Parity, categorized; 0, 1, 2, 3+; f Neopterin, quintiles; ≤5.84, 5.85–6.68, 6.69–7.50, 7.51–8.67, ≥8.68;* p value < 0.05; ** p value < 0.001. CI: indicates confidence interval.