Table 2.
Association between the TCF7L2-rs7903146 polymorphism and prevalence of T2D depending on the obesity status at baseline. Stratified logistic regression analysis.
| Non-Obese | p 3 for Interaction | Obese | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | OR | 95% CI | p-Value | Genotype × Obesity | n | OR | 95% CI | p-Value | |
| Model 1 1 | |||||||||
| TCF7L2 | 0.002 | ||||||||
| CC | 1424 | 1.00 | (reference) | 1346 | 1.00 | (reference) | |||
| CT | 1742 | 1.79 | (1.55–2.08) | 5.5 × 10−15 | 1507 | 1.28 | (1.10–1.49) | 0.0012 | |
| TT | 573 | 2.32 | (1.90–2.85) | 5.4 × 10−16 | 426 | 1.51 | (1.21–1.89) | 0.0003 | |
| p 4: 2.5 × 10−20 | p 4: 0.0002 | ||||||||
| Model 2 2 | |||||||||
| TCF7L2 | |||||||||
| CC | 1.00 | (reference) | 1.00 | (reference) | |||||
| CT | 1.78 | (1.54–2.09) | 1.4 × 10−14 | 0.003 | 1.27 | (1.09–1.48) | 0.0020 | ||
| TT | 2.26 | (1.84–2.78) | 1.6 × 10−14 | 1.53 | (1.22–1.92) | 0.0002 | |||
| p 4: 4.3 × 10−19 | p 4: 0.00017 | ||||||||
1 Model 1: adjusted for sex, age, and field center; 2 Model 2: adjusted for sex, age, field center, total energy intake, adherence to the Mediterranean diet, alcohol intake, smoking, physical activity, dyslipidemia, and hypertension; 3 p-value obtained for the interaction term between the TCF7L2 genotype and obesity in the corresponding multivariable logistic regression model; 4 p-value obtained for the global TCF7L2 polymorphism in the multivariable logistic regression model.