Table 3.
Association between the TCF7L2-rs7903146 polymorphism and obesity depending on T2D status. Stratified logistic regression analysis.
| Non-Diabetic | p 3 for Interaction | T2D Subjects | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | OR | 95% CI | p-Value | Genotype × T2D | n | OR | 95% CI | p-Value | |
| Model 1 1 | |||||||||
| TCF7L2 | 0.008 | ||||||||
| CC | 1612 | 1.00 | (reference) | 1158 | 1.00 | (reference) | |||
| CT | 1569 | 1.05 | (0.91–1.20) | 0.544 | 1680 | 0.78 | (0.67–0.91) | 0.001 | |
| TT | 426 | 0.96 | (0.77–1.19) | 0.694 | 573 | 0.64 | (0.52–0.78) | 2.0 × 10−5 | |
| p 4: 0.685 | p 4: 3.90 × 10−5 | ||||||||
| Model 2 2 | |||||||||
| TCF7L2 | |||||||||
| CC | 1.00 | (reference) | 1.00 | (reference) | |||||
| CT | 1.05 | (0.91–1.21) | 0.529 | 0.014 | 0.77 | (0.66–0.90) | 0.001 | ||
| TT | 0.93 | (0.74–1.16) | 0.493 | 0.63 | (0.51–0.78) | 1.6 × 10−5 | |||
| p 4: 0.528 | p 4: 3.02 × 10−5 | ||||||||
1 Model 1: adjusted for sex, age, and field center; 2 Model 2: adjusted for sex, age, field center, total energy intake, adherence to the Mediterranean diet, alcohol intake, smoking, physical activity, dyslipidemia, and hypertension; 3 p-value obtained for the interaction term between the TCF7L2 genotype and type-2 diabetes in the corresponding multivariable logistic regression model; 4 p-value obtained for the global TCF7L2 polymorphism in the multivariable logistic regression model.