Table 4.
Incidence and hazard ratios (HR) for T2D depending on the TCF7L2-rs7903146 polymorphism and stratified by obesity after 5.7 years of median follow-up.
| Obese Subjects 1 (n = 1693) | ||||||||||
| Cases | Non-Cases | Person-Years | Incidence Rate 4 | Model 12 | Model 23 | |||||
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |||||
| TCF7L2 genotypes | 0.960 | 0.965 | ||||||||
| CC | 73 | 677 | 4117.5 | 17.7 | 1.00 | (reference) | 1.00 | (reference) | ||
| CT | 79 | 669 | 4203.8 | 18.8 | 1.04 | (0.76–1.44) | 0.777 | 1.05 | (0.76–1.46) | 0.750 |
| TT | 21 | 174 | 1094.0 | 19.2 | 1.01 | (0.62–1.65) | 0.957 | 1.01 | (0.61–1.66) | 0.979 |
| Non-Obese Subjects (n = 1904) | ||||||||||
| Model 12 | Model 23 | |||||||||
| TCF7L2 genotypes | 0.035 | 0.045 | ||||||||
| CC | 56 | 803 | 4819.0 | 11.6 | 1.00 | (reference) | 1.00 | (reference) | ||
| CT | 57 | 758 | 4661.8 | 12.2 | 1.08 | (0.75–1.57) | 0.671 | 1.14 | (0.79–1.66) | 0.531 |
| TT | 26 | 204 | 1285.7 | 20.2 | 1.82 | (1.14–2.92) | 0.012 | 1.81 | (1.13–2.92) | 0.013 |
1 Obesity: BMI ≥30 kg/m2; 2 Model 1: Adjusted for sex, age, field center, and dietary intervention group; 3 Model 2: Adjusted for variables in model 1 plus total energy intake, adherence to the Mediterranean diet, alcohol intake, smoking, physical activity, dyslipidemia, and hypertension at baseline; 4 Crude incidence rates are expressed per 1000 person-years of follow-up.