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. 2016 Dec 7;8(12):795. doi: 10.3390/nu8120795

Figure 2.

Figure 2

The effect of carbohydrates and sweeteners on octanoyl ghrelin release in the ghrelinoma cell line are not mediated via the sweet taste receptor or the glucose transporters. Effect of preincubation (30 min) of MGN3-1 cells with a (a–c) TAS1R2-TAS1R3 antagonist (gurmarin, 30 µg/mL, n = 9); (d) SGLT1 inhibitor (phloridzin, 10 µM, n = 9) or (e) GLUT family antagonist (phloretin, 10–20 µM, n = 9) or their respective vehicle (Krebs with or without dimethylsulfoxide (DMSO)) on the effect of (a,d,e) 200 mM d-glucose; (b) 10% OFS; and (c) 200 mM sucralose compared to Krebs buffer on octanoyl ghrelin release in MGN3-1 cells. Results (mean ± SEM) are expressed relative to the control stimulation (Krebs buffer containing 11.1 mM d-glucose). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle, $ p < 0.05 vs. vehicle stimulated control.