Table 1.
Polymorphisms relating to key enzymes in the one-carbon metabolism that are potentially relevant to the development of Alzheimer’s disease (AD).
| Enzyme | Polymorphism | Reference |
|---|---|---|
| MTHFR | C677T | Schwahn and Rozen 2001 [20], Yamada et al., 2001 [21], Guenther et al., 1999 [22] |
| A1298C | Weisberg et al., 2001 [23] | |
| T1317C | Weisberg et al., 1998 [24] | |
| MS | A2756G | Leclerc et al., 1996 [25], Chen et al., 1997 [26] |
| MSR | A66G | Olteanu et al., 2002 [27] |
| C524T | Olteanu et al., 2002 [27] | |
| CBS | 68 bp insertion at exon 8 | Sebastio et al., 1995 [28] |
| G9276A | Nienaber-Rousseau et al., 2013 [29] | |
| 31 bp variable number of tandem repeats | Lievers et al., 2001 [30] | |
| SHMT | C1420T | Heil et al., 2001 [31] |
bp: base pairs; CBS: Cystathionine β-synthase; MSR: Methionine synthase reductase; MS: Methionine synthase; MTHFR: Methylenetetrahydrofolate reductase; SHMT: Serine hydroxymethyltransferase.