Fig. 3.

Graphic representation of relationship between chicken, human, and mouse CD30. (A) Tree representing the genetic distance between selected TNFR superfamily repeats generated by using protdist and fitch programs from the phylip package (14). Leaves are labeled with TNFR number, species (C, chicken; H, human; M, mouse), and a domain number representing the order of domains in the sequences. Chicken domains are surrounded by rectangles, solid for CD30 (TNR8), dotted for others. Larger dotted rectangles contain nearest neighbors to the chicken CD30 repeats. Numbers in parentheses show the percentage of trees in the bootstrap analysis in which the repeats in these rectangles were in the same clade. The circle covers part of the tree where bootstrap values were all <50%. (B) Graphic representation of chicken, mouse, and human CD30 protein structures. Similar repeats are similarly shaded. Repeats are numbered from the N terminus with the proposed source of duplicated segments in parentheses.