Table 2.

Overall number of events, rates per 10 000 person years, crude and adjusted hazard ratios for coeliac cohort compared with control cohort (reference group)

	Overall			First year of follow up after diagnosis			Follow up beyond year after diagnosis
Condition and cohort	No of participants*	Hazard ratio (95% CI)	Adjusted hazard ratio†(95% CI)	No of events	Rate/10 000 years	Adjusted hazard ratio†(95% CI)	No of events	Rate/10 000 years	Adjusted hazard ratio†(95% CI)
Any malignancy:							*
Control	23 433	1	1	111	52.7	1	395	56.5	1
Coeliac disease	4695	1.29 (1.06 to 1.55)	1.31 (1.08 to 1.59)	44	104.2	2.07 (1.45 to 2.96)	87	62.2	1.10 (0.87 to 1.39)
Gastrointestinal cancer:
Control	23 605	1	1	14	6.6	1	64	9.0	1.00
Coeliac disease	4724	1.85 (1.22 to 2.81)	1.95 (1.27 to 3.00)	9	21.1	3.31 (1.40 to 7.83)	20	14.1	1.65 (0.99 to 2.76)
Breast cancer:
Control	23 562	1	1	24	11.3	1	87	12.3	1
Coeliac disease	4725	0.35 (0.17 to 0.72)	0.31 (0.15 to 0.63)	3	7.0	0.60 (0.18 to 2.04)	5	3.5	0.24 (0.10 to 0.60)
Lung cancer:
Control	23 616	1	1	14	6.6	1	43	6.0	1
Coeliac disease	4728	0.34 (0.13 to 0.95)	0.37 (0.13 to 1.02)	1	2.3	0.40 (0.05 to 3.09)	3	2.1	0.37 (0.11 to 1.20)
Lymphoproliferative disease:
Control	23 612	1	1	6	2.8	1	17	2.4	1
Coeliac disease	4724	4.80 (2.71 to 8.50)	4.27 (2.36 to 7.74)	11	25.8	7.32 (2.65 to 20.24)	12	8.4	3.40 (1.58 to 7.34)
Prostate cancer:
Control	23 614	1	1	4	1.9	1	25	3.5	1
Coeliac disease	4730	0.99 (0.41 to 2.38)	1.05 (0.42 to 2.57)	1	2.3	1.30 (0.14 to 12.19)	5	3.5	1.03 (0.38 to 2.76)
Mortality:
Control	23 609	1	1	184	86.7	1	697	98.0	1
Coeliac disease	4728	1.31 (1.13 to 1.51)	1.39 (1.20 to 1.61)	73	171.0	2.09 (1.59 to 2.76)	163	114.6	1.23 (1.04 to 1.47)

^*Number vary as participants with event on same date or before start of follow up were excluded.

^†Adjusted for age, sex, body mass index, and smoking status.