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. 2016 Dec;22(12):2070–2077. doi: 10.3201/eid2212.160472

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Dose response of Heartland virus (HRTV)–infected interferon α/β/γ receptor–deficient (Ag129) mice. Mice of either sex were inoculated with 10⁴–10° PFU of HRTV/0.1 mL of inoculum. Mice were observed daily for death through day postinoculation 24. A) Percentage survival. B) Dose-associated HRTV viremias determined by plaque assays on Vero E6 cells. Different groups of 5 mice inoculated with the same dose of HRTV were bled every third day. Thus, a decrease in viremia was observed for the 10² PFU dose inoculum group days postinoculation 5 and 6. Error bars indicate SD.