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. 2016 Dec;22(12):2070–2077. doi: 10.3201/eid2212.160472

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Pathologic changes associated with infection of interferon-α/β/γ receptor–deficient (Ag129) mice with Heartland virus (HRTV). A) Mouse showing typical clinical signs of HRTV infection (ruffled fur, hunched posture, and squinting eyes). B) Dissected mouse showing an enlarged pale spleen (arrow). C–E) Hematoxylin and eosin staining (left panels) and immunohistochemical staining (right panels) for HRTV nucleocapsid protein of spleen (C), liver (D), and kidney (E) of Ag129 mice at 5–7 days postinoculation with 10⁴ PFU virus. Original magnifications: C, ×100; D, ×50; E, ×100.