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. 2016 Dec;22(12):2137–2141. doi: 10.3201/eid2212.160611

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Pathogenesis of influenza virus rH5N1 and pH5N1 2.3.2.1a genotypes in vitro and in vivo. A) Replication kinetics of rH5N1 and pH5N1 in Madin-Darby canine kidney (mammalian) cells. B) Replication kinetics of rH5N1 and pH5N1 in chicken embryonic fibroblast (avian) cells. C) Oropharyngeal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmission model in 5-week-old White Leghorn chickens. D) Cloacal shedding and transmissibility of rH5N1 and pH5N1 in a single-virus transmission model in 5-week-old White Leghorn chickens. Naive chickens were co-housed with donors infected with either Ck/22478 (pH5N1) or Ck/Bh/346 (rH5N1) (C and D). The dashed line in each panel represents the limit of virus detection. ANOVA, analysis of variance; Ck/22478, A/chicken/Bangladesh/22478; Ck/Bh/346, A/chicken/Bhutan/346/2012; Dk/BD/23126, A/duck/Bangladesh/23126; Dk/BD/19097/2013, A/duck/Bangladesh/19097; EID, egg infectious dose; dpi, days postinoculation; hpi, hours postinfection; pH5N1, pandemic H1N1; rH5N1, reassortant H5N1.