Table 1.
The presence of Ndrg1 and HIF-1α proteins in various normal and malignant human tissues
| TISSUE (n) | Ndrg1 | HIF-1α | ||||||
| - | + | ++ | +++ | - | + | ++ | +++ | |
| Normal Lung (30) | 24 | 6 | - | - | 4 | 11 | 15 | - |
| Lung Cancer (30) | - | - | 3 | 27 | - | 6 | 21 | 3 |
| Normal Liver (20) | 7 | 13 | - | - | 2 | 15 | 3 | - |
| Liver Cancer (20) | - | - | 4 | 16 | - | 11 | 2 | 7 |
| Normal Breast (18) | 3 | 13 | 2 | - | 1 | 9 | 8 | - |
| Breast Cancer (20) | - | - | 6 | 14 | - | 4 | 7 | 9 |
| Smooth Muscle (30) | 12 | 15 | 3 | - | 9 | 11 | 10 | - |
| S.M. Cancer (24) | - | 6 | 7 | 11 | - | 9 | 12 | 3 |
| Normal Brain (28) | 24 | 4 | - | - | 18 | 10 | - | - |
| Brain Cancer (36) | - | - | 11 | 25 | - | - | 15 | 21 |
| Normal Kidney (15) | - | 6 | 8 | 1 | - | 5 | 10 | - |
| Kidney Cancer (22) | - | - | 7 | 15 | - | 7 | 9 | 6 |
| Normal Skin (20) | 14 | 6 | - | - | 11 | 9 | - | - |
| Melanoma (10) | - | - | - | 10 | 4 | 6 | - | - |
Tissues were stained immunohistochemically with antibodies against Ndrg1 and HIF-1α as described in 'Methods' section. Each value shown in the table is from a single tissue sample from an individual patient. The numbers in parentheses (n) represent the total numbers of tissues stained with both antibodies. The expression levels were marked as follows: (-) no staining; (+) weak; (++) moderate; (+++) overexpression.