Figure 2.

Mutational landscape identified in 92 different tumors based on functional pathways. (A): Types of alterations and number of alterations were reflective of tumor subtypes profiled. (B): For 9 of the 10 most frequent pathways, the frequency of genes with alterations within those pathways occurring is depicted. Wnt/β-catenin is not shown but had only two genes represented: APC (adenomatous polyposis coli) (n = 8) and MSH6 (MutS Homolog 6) (n = 1). Numbers represent the frequency of alterations affecting that gene.