. Author manuscript; available in PMC: 2017 Nov 21.

Published in final edited form as: ChemMedChem. 2016 Oct 18;11(22):2511–2521. doi: 10.1002/cmdc.201600421

Table 4.

Effects of SecA inhibitors on levels of efflux pumps in E. coli. MIC (μg/mL)

Inhibitors	Addition	W4573 Ram1292	AcrAB⁻ Ram1340	AcrAB⁺⁺ in Ram1340	MexCD-OprJ⁺ in Ram1340	MexCD⁺ in Ram1340
SCA-112	None	>667*	>667*	>667*	>667*	>667*
	PMBN	0.3	0.2	0.3	0.4	0.4
	NAB7061	0.2	0.1	0.2	0.1	≤0.1
SCA-107	None	>590*	>590*	>590*	>590*	>590*
	PMBN	0.7	0.7	0.7	0.7	0.7
	NAB7061	0.7	0.7	0.7	0.4	≤0.05

PMBN used: 12.5 μg/mL; NAB7061 used : 2 μg/mL. E. coli parental strain W4573(Ram1292) and strains Ram1340(AcrAB⁻) contain P. aeruginosa efflux pump MexCD⁺ or MexCD-OprJ⁺.