Table 1.
Demographic and clinical characteristics of patients with stage I/II uterine carcinosarcoma by treatment received.
| Variable | OBS (N = 75)
|
CT (N = 33)
|
RT (N = 37)
|
CT + RT (N = 43)
|
p-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | ||
| Age | 75 | 70.3 (11.4) | 33 | 66.5 (11.5) | 37 | 67.2 (12.0) | 43 | 64.9 (8.6) | 0.07 |
| Year of diagnosis | 75 | 2005.3 (4.3) | 33 | 2007.9 (4.4) | 37 | 2004.4 (3.7) | 43 | 2007.9 (2.8) | <0.0001 |
| Body mass index (BMI) | 66 | 31.4 (7.3) | 33 | 32.6 (9.4) | 30 | 33.1 (9.3) | 42 | 32.2 (8.7) | 0.82 |
| Parity | 73 | 2.8 (1.9) | 31 | 2.3 (2.6) | 36 | 3.9 (3.0) | 42 | 2.5 (1.8) | 0.02 |
| N | % | N | % | N | % | N | % | p-value | |
|
| |||||||||
| Race | 0.05 | ||||||||
| White | 27 | 37.0 | 21 | 65.6 | 17 | 47.2 | 22 | 51.2 | |
| Black | 44 | 60.3 | 9 | 28.1 | 17 | 47.2 | 17 | 39.5 | |
| Hispanic | 1 | 1.4 | 0 | 0.0 | 0 | 0.0 | 1 | 2.3 | |
| Other | 1 | 1.4 | 2 | 6.3 | 2 | 5.6 | 3 | 7.0 | |
| Missing | 2 | 1 | 1 | 0 | |||||
| Smoking | 0.20 | ||||||||
| Yes | 13 | 18.1 | 9 | 29.0 | 9 | 27.3 | 5 | 11.6 | |
| No | 59 | 81.9 | 22 | 71.0 | 24 | 72.7 | 38 | 88.4 | |
| Missing | 3 | 2 | 4 | 0 | |||||
| Clinic site | 0.02 | ||||||||
| 1 | 21 | 28.0 | 13 | 39.4 | 11 | 29.7 | 23 | 53.5 | |
| 2 | 10 | 13.3 | 9 | 27.3 | 9 | 24.3 | 8 | 18.6 | |
| 3 | 29 | 38.7 | 10 | 30.3 | 14 | 37.8 | 9 | 20.9 | |
| 4 | 15 | 20.0 | 1 | 3.0 | 3 | 8.1 | 3 | 7.0 | |
| Cancer history | 0.04 | ||||||||
| Yes | 14 | 18.7 | 13 | 39.4 | 5 | 13.5 | 8 | 18.6 | |
| No | 61 | 81.3 | 20 | 60.6 | 32 | 86.5 | 35 | 81.4 | |
| Radiation history | 0.45 | ||||||||
| Yes | 4 | 5.3 | 4 | 12.1 | 1 | 2.7 | 2 | 4.7 | |
| No | 71 | 94.7 | 29 | 87.9 | 36 | 97.3 | 41 | 95.4 | |
| LSVI | 0.18 | ||||||||
| Yes | 20 | 27.0 | 11 | 66.7 | 17 | 47.2 | 17 | 39.5 | |
| No | 54 | 73.0 | 22 | 33.3 | 19 | 52.9 | 26 | 60.5 | |
| Missing | 1 | 0 | 1 | 0 | |||||
| Stage | 0.001 | ||||||||
| I | 70 | 93.3 | 29 | 87.9 | 26 | 70.3 | 30 | 69.8 | |
| II | 5 | 6.7 | 4 | 12.1 | 11 | 29.7 | 13 | 30.2 | |
| Residual disease | 0.30 | ||||||||
| Yes | 0 | 0.0 | 1 | 3.0 | 1 | 2.7 | 1 | 2.4 | |
| No | 75 | 100.0 | 32 | 96.7 | 36 | 97.3 | 41 | 97.6 | |
| Missing | 0 | 0 | 0 | 1 | |||||
| Cervix + disease | 0.003 | ||||||||
| No | 69 | 92.0 | 30 | 90.9 | 26 | 70.3 | 30 | 71.4 | |
| Yes | 6 | 8.0 | 3 | 9.1 | 11 | 29.7 | 12 | 28.6 | |
| Missing | 0 | 0 | 1 | ||||||
| Ovaries + disease | 0.18 | ||||||||
| No | 75 | 100.0 | 32 | 97.0 | 37 | 100.0 | 43 | 100.0 | |
| Yes | 0 | 0.0 | 1 | 3.0 | 0 | 0.0 | 0 | 0.0 | |
| Uterine serosa + disease | 1.00 | ||||||||
| No | 74 | 98.7 | 33 | 100.0 | 37 | 100.0 | 42 | 97.7 | |
| Yes | 1 | 1.3 | 0 | 0.0 | 0 | 0.0 | 1 | 2.3 | |
| Vagina + disease | – | ||||||||
| No | 75 | 100.0 | 33 | 100.0 | 37 | 100.0 | 41 | 100.0 | |
| Yes | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | |
| Missing | 0 | 0 | 0 | 2 | |||||
| Recurrence outcomes | |||||||||
| Recurrence | 0.42 | ||||||||
| Yes | 30 | 42.9 | 15 | 45.5 | 11 | 30.6 | 14 | 32.6 | |
| No | 40 | 57.1 | 18 | 54.6 | 25 | 69.4 | 29 | 67.4 | |
| Unknown | 5 | 0 | 1 | 0 | |||||
| Site of first recurrence | 0.07 | ||||||||
| Vaginal only | 10 | 34.5 | 7 | 46.7 | 2 | 18.2 | 1 | 7.1 | |
| Other pelvic | 10 | 34.5 | 6 | 40.0 | 2 | 18.2 | 6 | 42.9 | |
| Extra pelvic/multiple | 9 | 31.0 | 2 | 13.3 | 7 | 63.6 | 7 | 50.0 | |