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. Author manuscript; available in PMC: 2016 Dec 27.
Published in final edited form as: Med Mycol. 2013 Dec 22;52(2):131–139. doi: 10.1093/mmy/myt007

Table 1.

. Comparison of echinocandin activity on planktonic (pMIC80) and sessile (sMIC80) cells of Candida albicans fks1 mutants.

Anidulafungin (μg/ml)
 Caspofungin (μg/ml)
 Micafungin (μg/ml)
C. albicans strain (mutation) pMIC80 sMIC80 pMIC80 sMIC80 pMIC80 sMIC80
2762 (F641S) ≤0.25 2 2 8 1 8
32746 (F641S) 0.5 2 2 ≥128 1 >128
4254 (F641S) ≤0.25 ≥128 2 ≥128 1 ≥128
4715 (F641S) ≤0.25 2 2 8 1 4
41509 (F641S) 0.5 4 64 8 2 8
42996 (F641S) ≤0.25 4 2 4 1 8
43001 (F641S) ≤0.25 2 2 8 1 8
41301 (F641S) ≤0.25 ≥128 2 ≥128 1 ≥128
42379 (S645P) 0.5 4 4 ≥128 2 16
53264 (S645P) 0.5 4 8 16 2 16
42286 (S645P/S) ≤0.25 4 2 4 1 8
5415 (S645P/H) ≤0.25 2 2 ≥128 1 8
SC5314 (WT) ≤0.25 ≤0.25 1 2 ≤0.25 ≤0.25

The MIC80 represents the lowest echinocandin concentration that inhibited 80% of the metabolic activity of the cells.

Abbreviations: MIC, minimum inhibitory concentration; WT, wild-type FKS1.