Skip to main content
. Author manuscript; available in PMC: 2017 Oct 17.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Sep 20;55(43):13562–13566. doi: 10.1002/anie.201607278

Table 2.

Substrate scope of Mb(L29S,H64V,V68F).[a]

graphic file with name nihms835888u3.jpg
Sulfide Diazo reag. Product % conv. (TON) TTN[b] ee [%][c]
1 2b graphic file with name nihms835888t1.jpg
13 		>99% (>1,000) 8,170 6%
1 2c graphic file with name nihms835888t2.jpg
14 		>99% (>1,000) 8,820 9%
1 2d graphic file with name nihms835888t3.jpg
15 		94% (940) 3,570 47%
4 2a graphic file with name nihms835888t4.jpg
16 		>99% (>1,000) 5,050 20%
−60%[d]
5 2a graphic file with name nihms835888t5.jpg
17 		>99% (>1,000) 5,960 40%
6 2a graphic file with name nihms835888t6.jpg
18 		57% (570) 1,000 18%
58%[d]
7 2a graphic file with name nihms835888t7.jpg
19 		>99% (>1,000) 8,120 57/59%
1:1 d.r.
8 2a graphic file with name nihms835888t8.jpg
20 		78% (780) 7,040 10%
9 2a graphic file with name nihms835888t9.jpg
21 		93% (930) 5,470 43%
10 2a graphic file with name nihms835888t10.jpg
22 		35% (350) 3,570 38%
11 2a graphic file with name nihms835888t11.jpg
23 		8% (80) 125 n.d.[e]
12 2a graphic file with name nihms835888t12.jpg
24 		86% (860) 4,190 19%
[a]

Under standard reactions conditions as described in Table 1.

[b]

Using 1 μM Mb catalyst instead of 10 μM.

[c]

As determined by chiral GC or Supercritical Fluid Chromatography (SFC).

[d]

Using Mb(H64V,V68A).

[e]

Enantiomers could not be resolved.