Skip to main content
. Author manuscript; available in PMC: 2017 Aug 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Aug 5;55(36):10786–10790. doi: 10.1002/anie.201604106

Scheme 2.

Scheme 2

Step-wise 18F-Difluoromethylarene Formation of Tertiary Amines. Reaction conditions: Arene 2 (10 μmol), LiHMDS (1.0 M in THF, 1.3 equiv), THF (0.25 mL), −78 °C, 45 min. then NBS (1.0 equiv), THF (0.1 mL), −78 °C, 45 min. (b) TEAB (3.5 mg), chlorobenzene (0.2 mL), MeCN (20 μL), 100 °C, 5 min, then KOH aqueous solution (45 w%, 40 μL), 100 °C, 15 min.