Table 2.
Variable | All patients (n=219) |
Low HRQOL (n=111) |
High HRQOL (n=108) |
P-value |
---|---|---|---|---|
CD, n (%) | 146 (66.7) | 76 (68.5) | 70 (64.8) | 0.566 |
Active disease, n (%) | 56 (25.6) | 46 (41.4) | 10 (9.3) | <0.001 |
HBI (CD, n=146), median (range) | 2.0 (0–11) | 4.0 (0–11) | 1.0 (0–7) | |
PMS (UC, n=73), median (range) | 1.0 (0–9) | 3.0 (0–9) | 0.0 (0–4) | |
Disease duration (years), mean ± SD | 5.2±4.1 | 5.6±4.5 | 5.5±4.4 | 0.916 |
Age of diagnosis, years (CD, n=146), n (%) | 0.606 | |||
A1 (≤16) | 6 (4.1) | 3 (3.9) | 3 (4.3) | |
A2 (17–40) | 125 (85.6) | 67 (88.2) | 58 (82.9) | |
A3 (>40) | 15 (10.3) | 6 (7.9) | 9 (12.9) | |
Location (CD, n=146), n (%) | 0.574 | |||
L1 (ileal) | 16 (11) | 10 (13.2) | 6 (8.6) | |
L2 (colonic) | 11 (7.6) | 4 (5.3) | 7 (10.0) | |
L3 (ileocolonic) | 98 (67.1) | 52 (68.4) | 46 (65.7) | |
L4 (upper GI tract) | 21 (14.4) | 10 (13.2) | 11 (15.7) | |
Behavior (CD, n=146), n (%) | 0.910 | |||
B1 (inflammatory) | 62 (42.5) | 31 (40.8) | 31 (44.3) | |
B2 (stricturing) | 47 (32.2) | 25 (32.9) | 22 (31.4) | |
B3 (penetrating) | 37 (25.3) | 20 (26.3) | 17 (24.3) | |
Perianal disease (CD, n=146), n (%) | 0.692 | |||
No | 102 (69.9) | 52 (68.4) | 50 (71.4) | |
Yes | 44 (30.1) | 24 (31.6) | 20 (28.6) | |
Extent of colitis (UC, n=73), n (%) | 0.161 | |||
E1 (proctitis) | 10 (13.7) | 2 (5.7) | 8 (21.1) | |
E2 (left side) | 30 (41.1) | 16 (45.7) | 14 (36.8) | |
E3 (pancolitis) | 33 (45.2) | 17 (48.6) | 16 (42.1) | |
Treatment, n (%) | 0.011 | |||
No treatment | 11 (5.0) | 7 (6.3) | 4 (3.7) | |
Mesalazine | 19 (8.7) | 14 (12.6) | 5 (4.6) | |
Steroid | 18 (8.2) | 14 (12.6) | 4 (3.7) | |
Immunosuppressive | 110 (50.2) | 47 (42.3) | 63 (58.3) | |
Biologics | 61 (27.9) | 29 (26.1) | 32 (29.6) | |
Relapses of IBD in last year, n (%) | 75 (34.2) | 50 (45.0) | 25 (23.1) | 0.001 |
Hospitalizations for IBD in last year, n (%) | 85 (38.8) | 54 (48.6) | 31 (28.7) | 0.002 |
History of surgical resection, n (%) | 50 (22.8) | 28 (25.2) | 22 (20.4) | 0.392 |
Abbreviations: HRQOL, health-related quality of life; CD, Crohn’s disease; HBI, Harvey and Bradshaw Index; PMS, partial Mayo score; UC, ulcerative colitis; GI, gastrointestinal; IBD, inflammatory bowel disease.