Table 3.
Differential miRNA expression between colon carcinoma and normal colonic mucosa uniquely associated with either sucrose or carbohydrate intake
| miRNA | Tumor | Normal | β | p-value | q-value |
|---|---|---|---|---|---|
|
| |||||
| Mean | Mean | ||||
| Sucrose | |||||
| hsa_miR_1229_3p | 15.00 | 17.87 | −0.0680 | 0.0454 | 0.0976 |
| hsa_miR_1247_3p | 27.62 | 26.20 | −0.0738 | 0.0300 | 0.0797 |
| hsa_miR_1273g_5p | 9.21 | 10.05 | 0.0943 | 0.0064 | 0.0641 |
| hsa_miR_155_5p | 44.51 | 46.29 | −0.0699 | 0.0422 | 0.0947 |
| hsa_miR_181a_5p | 34.21 | 24.91 | −0.0778 | 0.0245 | 0.0726 |
| hsa_miR_200a_5p | 6.09 | 5.12 | 0.0795 | 0.0238 | 0.0723 |
| hsa_miR_210 | 23.66 | 14.90 | −0.0815 | 0.0165 | 0.0641 |
| hsa_miR_2277_3p | 3.86 | 5.01 | 0.0857 | 0.0125 | 0.0641 |
| hsa_miR_302c_5p | 2.70 | 2.40 | 0.0688 | 0.0473 | 0.0993 |
| hsa_miR_3170 | 1.86 | 2.44 | 0.0888 | 0.0108 | 0.0641 |
| hsa_miR_320b | 82.25 | 80.23 | −0.0765 | 0.0258 | 0.0728 |
| hsa_miR_3614_5p | 5.13 | 6.55 | 0.0715 | 0.0381 | 0.0894 |
| hsa_miR_3648 | 331.00 | 274.75 | −0.0767 | 0.0246 | 0.0726 |
| hsa_miR_365b_5p | 13.34 | 14.46 | 0.0704 | 0.0424 | 0.0947 |
| hsa_miR_373_5p | 17.58 | 18.43 | −0.0718 | 0.0348 | 0.0871 |
| hsa_miR_3976 | 2.15 | 1.11 | 0.0817 | 0.0177 | 0.0641 |
| hsa_miR_4419a | 69.63 | 66.94 | −0.0728 | 0.0374 | 0.0888 |
| hsa_miR_4448 | 9.30 | 9.04 | 0.0828 | 0.0174 | 0.0641 |
| hsa_miR_4484 | 64.10 | 71.60 | −0.0754 | 0.0261 | 0.0728 |
| hsa_miR_4488 | 109.70 | 113.97 | −0.0846 | 0.0110 | 0.0641 |
| hsa_miR_4532 | 316.22 | 368.80 | −0.0776 | 0.0256 | 0.0728 |
| hsa_miR_4700_5p | 1.34 | 0.96 | 0.0693 | 0.0459 | 0.0977 |
| hsa_miR_4715_5p | 4.40 | 5.06 | 0.0802 | 0.0208 | 0.0682 |
| hsa_miR_4717_3p | 3.67 | 3.39 | 0.0912 | 0.0082 | 0.0641 |
| hsa_miR_4733_5p | 67.07 | 69.46 | −0.0753 | 0.0287 | 0.0780 |
| hsa_miR_4793_3p | 5.89 | 6.42 | 0.0815 | 0.0195 | 0.0666 |
| hsa_miR_5003_3p | 19.76 | 20.35 | −0.0704 | 0.0408 | 0.0921 |
| hsa_miR_602 | 44.22 | 47.11 | −0.0707 | 0.0378 | 0.0892 |
| hsa_miR_6069 | 18.95 | 19.15 | −0.0674 | 0.0467 | 0.0989 |
| hsa_miR_6075 | 209.46 | 246.60 | −0.0713 | 0.0355 | 0.0873 |
| hsa_miR_6134 | 3.05 | 3.18 | 0.0752 | 0.0293 | 0.0786 |
| hsa_miR_659_5p | 2.28 | 3.28 | 0.0862 | 0.0134 | 0.0641 |
| Carbohydrate | |||||
| hsa_miR_1291 | 5.62 | 3.31 | 0.0966 | 0.0053 | 0.0350 |
| hsa_miR_129_5p | 9.26 | 9.98 | −0.0973 | 0.0048 | 0.0350 |
| hsa_miR_1305 | 112.80 | 129.42 | −0.0920 | 0.0081 | 0.0350 |
| hsa_miR_30c_1_3p | 10.17 | 11.17 | −0.0911 | 0.0082 | 0.0350 |
| hsa_miR_3198 | 165.30 | 171.97 | −0.0927 | 0.0076 | 0.0350 |
| hsa_miR_3945 | 43.34 | 47.78 | −0.0938 | 0.0063 | 0.0350 |
| hsa_miR_4459 | 20,580.45 | 24,456.49 | −0.0951 | 0.0075 | 0.0350 |
| hsa_miR_4470 | 34.38 | 40.65 | −0.1108 | 0.0016 | 0.0350 |
| hsa_miR_4499 | 376.55 | 430.33 | −0.1030 | 0.0031 | 0.0350 |
| hsa_miR_4656 | 182.68 | 185.98 | −0.0909 | 0.0084 | 0.0350 |
| hsa_miR_575 | 561.79 | 607.76 | −0.1092 | 0.0014 | 0.0350 |
| hsa_miR_6131 | 129.70 | 148.03 | −0.0925 | 0.0071 | 0.0350 |
| hsa_miR_1236_5p | 186.86 | 188.18 | −0.0908 | 0.0092 | 0.0357 |
| hsa_miR_221_3p | 11.21 | 2.53 | 0.0896 | 0.0093 | 0.0357 |
| hsa_miR_3652 | 150.82 | 160.30 | −0.0909 | 0.0093 | 0.0357 |
| hsa_miR_769_3p | 21.60 | 24.95 | −0.0900 | 0.0091 | 0.0357 |
| hsa_miR_4740_5p | 31.44 | 33.08 | −0.0898 | 0.0103 | 0.0367 |
| hsa_miR_1288 | 50.64 | 56.68 | −0.0896 | 0.0111 | 0.0374 |
| hsa_miR_4730 | 6.40 | 5.81 | 0.0882 | 0.0119 | 0.0386 |
| hsa_miR_4314 | 60.89 | 63.69 | −0.0866 | 0.0135 | 0.0388 |
| hsa_miR_4682 | 2.04 | 1.82 | 0.0873 | 0.0133 | 0.0388 |
| hsa_miR_196b_5p | 15.41 | 6.06 | 0.0833 | 0.0156 | 0.0410 |
| hsa_miR_4462 | 328.28 | 365.23 | −0.0829 | 0.0157 | 0.0410 |
| hsa_miR_4716_3p | 103.29 | 116.31 | −0.0848 | 0.0153 | 0.0410 |
| hsa_miR_3972 | 3.95 | 2.61 | 0.0841 | 0.0170 | 0.0420 |
| hsa_miR_4739 | 913.21 | 1,025.15 | −0.0858 | 0.0171 | 0.0420 |
| hsa_miR_3925_5p | 42.61 | 46.66 | −0.0825 | 0.0184 | 0.0435 |
| hsa_miR_4665_5p | 59.37 | 61.84 | −0.0836 | 0.0185 | 0.0435 |
| hsa_miR_1207_5p | 1,881.80 | 2,044.90 | −0.0825 | 0.0191 | 0.0438 |
| hsa_miR_378a_3p | 112.01 | 146.82 | −0.0806 | 0.0196 | 0.0438 |
| hsa_miR_4701_3p | 78.10 | 75.38 | −0.0798 | 0.0201 | 0.0438 |
| hsa_miR_4793_5p | 225.94 | 220.22 | −0.0787 | 0.0192 | 0.0438 |
| hsa_miR_497_5p | 1.21 | 5.89 | 0.0800 | 0.0196 | 0.0438 |
| hsa_miR_5700 | 2.39 | 2.49 | 0.0806 | 0.0201 | 0.0438 |
| hsa_miR_5581_5p | 106.65 | 121.34 | −0.0816 | 0.0206 | 0.0441 |
| hsa_miR_4496 | 56.08 | 60.47 | −0.0793 | 0.0213 | 0.0448 |
| hsa_miR_3130_5p | 11.48 | 11.83 | 0.0815 | 0.0219 | 0.0455 |
| hsa_miR_4737 | 1.10 | 0.94 | 0.0797 | 0.0220 | 0.0455 |
| hsa_miR_5194 | 54.57 | 60.38 | −0.0799 | 0.0227 | 0.0466 |
| hsa_miR_6129 | 78.07 | 86.34 | −0.0788 | 0.0231 | 0.0469 |
| hsa_miR_6717_5p | 118.74 | 134.59 | −0.0798 | 0.0236 | 0.0474 |
| hsa_miR_4294 | 21.43 | 22.45 | −0.0784 | 0.0239 | 0.0475 |
| hsa_miR_4713_3p | 229.14 | 258.22 | −0.0785 | 0.0238 | 0.0475 |
| hsa_miR_1307_5p | 51.08 | 67.75 | −0.0772 | 0.0241 | 0.0476 |
| hsa_miR_3185 | 18.39 | 17.80 | −0.0776 | 0.0253 | 0.0478 |
| hsa_miR_4304 | 16.80 | 18.22 | −0.0784 | 0.0247 | 0.0478 |
| hsa_miR_4673 | 79.93 | 94.86 | −0.0783 | 0.0252 | 0.0478 |
| hsa_miR_494 | 15,260.32 | 15,700.29 | −0.0771 | 0.0247 | 0.0478 |
| hsa_miR_5088 | 47.41 | 55.74 | −0.0795 | 0.0250 | 0.0478 |
| hsa_miR_6515_3p | 8.54 | 8.71 | 0.0793 | 0.0251 | 0.0478 |
| hsa_miR_518c_5p | 1.84 | 2.58 | 0.0791 | 0.0256 | 0.0479 |
| hsa_miR_4646_5p | 110.21 | 112.97 | −0.0780 | 0.0263 | 0.0483 |
| hsa_miR_378i | 56.62 | 73.03 | −0.0757 | 0.0276 | 0.0490 |
| hsa_miR_887 | 53.78 | 63.17 | −0.0765 | 0.0287 | 0.0500 |
| hsa_miR_3679_5p | 672.88 | 742.50 | −0.0760 | 0.0291 | 0.0504 |
| hsa_miR_345_3p | 62.14 | 60.39 | −0.0749 | 0.0295 | 0.0509 |
| hsa_miR_3125 | 56.40 | 60.80 | −0.0747 | 0.0305 | 0.0523 |
| hsa_miR_191_3p | 8.84 | 9.03 | 0.0749 | 0.0327 | 0.0542 |
| hsa_miR_4508 | 48.75 | 57.69 | −0.0752 | 0.0324 | 0.0542 |
| hsa_miR_622 | 89.80 | 88.61 | −0.0747 | 0.0323 | 0.0542 |
| hsa_miR_4690_5p | 164.97 | 209.18 | −0.0736 | 0.0342 | 0.0560 |
| hsa_miR_4419b | 25.39 | 26.54 | −0.0735 | 0.0354 | 0.0568 |
| hsa_miR_4534 | 224.12 | 255.34 | −0.0735 | 0.0355 | 0.0568 |
| hsa_miR_4659b_3p | 4.15 | 5.06 | 0.0750 | 0.0367 | 0.0583 |
| hsa_miR_520e | 11.01 | 14.21 | −0.0736 | 0.0371 | 0.0585 |
| hsa_miR_3150b_5p | 14.06 | 19.14 | −0.0731 | 0.0374 | 0.0587 |
| hsa_miR_590_5p | 1.93 | 2.43 | 0.0743 | 0.0380 | 0.0594 |
| hsa_miR_4538 | 140.02 | 191.59 | −0.0741 | 0.0393 | 0.0609 |
| hsa_miR_1303 | 3.89 | 4.35 | 0.0708 | 0.0395 | 0.0610 |
| hsa_miR_513c_5p | 91.98 | 100.86 | −0.0726 | 0.0398 | 0.0612 |
| hsa_miR_339_3p | 3.81 | 3.95 | 0.0725 | 0.0401 | 0.0613 |
| hsa_miR_1470 | 4.48 | 5.86 | 0.0715 | 0.0409 | 0.0620 |
| hsa_miR_550b_2_5p | 37.51 | 39.99 | −0.0712 | 0.0409 | 0.0620 |
| hsa_miR_3195 | 892.68 | 1,067.06 | −0.0697 | 0.0424 | 0.0635 |
| hsa_miR_1208 | 29.73 | 32.93 | −0.0704 | 0.0430 | 0.0639 |
| hsa_miR_2276 | 101.73 | 96.46 | −0.0715 | 0.0429 | 0.0639 |
| hsa_miR_3200_5p | 25.29 | 28.98 | −0.0702 | 0.0441 | 0.0648 |
| hsa_miR_4710 | 43.12 | 40.75 | −0.0693 | 0.0446 | 0.0651 |
| hsa_miR_500a_5p | 20.68 | 23.85 | −0.0694 | 0.0454 | 0.0658 |
| hsa_miR_4535 | 67.37 | 72.01 | −0.0690 | 0.0478 | 0.0687 |
| hsa_miR_630 | 345.63 | 402.87 | −0.0678 | 0.0486 | 0.0695 |
| hsa_miR_4253 | 45.58 | 48.10 | −0.0685 | 0.0494 | 0.0700 |
| hsa_miR_452_5p | 8.81 | 10.34 | 0.0683 | 0.0496 | 0.0700 |
| hsa_miR_510 | 1.10 | 0.97 | 0.0674 | 0.0498 | 0.0700 |
Abbreviation: miRNA, micro RNA.