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. Author manuscript; available in PMC: 2016 Dec 27.
Published in final edited form as: J Am Chem Soc. 2016 May 18;138(21):6754–6764. doi: 10.1021/jacs.6b00360

Table 2.

Binding Affinities of Mitragyna Alkaloids at Human Opioid Receptors

Ki ± SEM (µM)a
Compound hMOR hKOR hDOR
mitagynine 0.233 ± 0.048 0.772 ± 0.207 > 10
paynantheine 0.410 ± 0.152 2.56 ± 0.37 > 10
speciogynine 0.728 ± 0.061 3.20 ± 0.36 > 10
speciociliatine 0.560 ± 0.168 0.329 ± 0.112 > 10
7-OH 0.047 ± 0.018 0.188 ± 0.038 0.219 ± 0.041
a

All data points represent mean ± SEM (µM) of n ≥ 3.