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Glial regulation of glutamate modulation of magnocellular neurons. Under baseline conditions, astrocytes regulate the activation of presynaptic metabotropic glutamate receptors by uptake of extracellular glutamate by glial transporters, which prevents glutamate access to the receptors. Glial retraction uncovers the presynaptic receptors and allows their activation by glutamate, which provides a feedback autoinhibition of glutamate release.
