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Correlation between T0 ctDNA concentration tertiles and (A) tumor burden defined by the sum of the RECIST target lesions (Mann-Whitney test) and (B) presence of liver metastasis (Fisher’s exact test). (C) Correlation between positive ctDNA at baseline and Ki67 proliferative index expressed as a % of positive cells in a subset of tumors with available tissue (n = 19, Mann-Whitney test). *p < 0.05, **p < 0.005, ***p < 0.001.
