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. 2016 Dec 13;12(12):e1006104. doi: 10.1371/journal.ppat.1006104

Fig 6. Functionality of SIV-specific T cell responses increased during SIVΔnef vaccination.

Fig 6

(A) While the total SIV-specific T cell response as measured by IFN-γ ELISpot decreased during the first 20 weeks of SIVΔnef vaccination, the Gag-specific T cell response was maintained over time. Error bars reflect SEM. (B) Gag-specific CD4 T cells at week 20 expressed significantly higher levels of IFN-γ (p = 0.0067), IL-2 (p = 0.0049), and TNF-α (p = 0.0052) than Gag-specific CD4 T cells at week 5 (two-tailed paired t-test). (C) Gag-specific CD8 T cells at weeks 20 and 40 expressed significantly higher levels of IL-2 than at week 5 (two-tailed paired t-test). (D) Trifunctional Gag-specific CD4 T cell responses were significantly higher at week 20 (p = 0.0235) and week 40 (p = 0.0433) than at week 5; dual-functional CD4 T cell responses were also significantly higher at week 20 (p = 0.0267) and week 40 (p = 0.0344) (two-tailed Wilcoxon test). (E) Trifunctional Gag-specific CD8 T cell responses increased significantly between weeks 5 and 20 (p = 0.0234) and between weeks 5 and 40 (p = 0.0053); dual-functional CD8 T cell responses also increased significantly from week 5 to week 20 (p = 0.0070) and week 40 (p = 0.0020) (two-tailed Wilcoxon test).