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. 2016 Dec 13;12(12):e1006104. doi: 10.1371/journal.ppat.1006104

Fig 10. Maturation of CD8 T cell response to transitional memory phenotype during SIVΔnef vaccination.

Fig 10

(A) Increased expression of CD28 in CM9-specific CD8 T cells in SLT (p = 0.0018) and FGT (p = 0.0010) between 5 and 20 weeks post-SIVΔnef vaccination. (B) No change in CCR expression between weeks 5 and 20 post-vaccination with SIVΔnef. (C) Significant decrease in perforin levels in CM9-specific CD8 T cells across all tissues (p<0.0001). (D) Increased expression of CXCR3 across all tissues between weeks 5 and 20 post-vaccination with SIVΔnef (p≤0.0367). (E) Significant decrease in Ki-67 levels in peripheral blood (p = 0.0156) and SLT (p = 0.0308) but no decrease in GM and FGT. (F) Ki-67 expression levels were higher in CM9-specific CD8 T cells than in SL8-specific CD8 T ells in SLT (p = 0.0058) and in GM (p = 0.0203) but not in peripheral blood or FGT. All statistical analyses were conducted using two-tailed unpaired t-tests.