Figure 1. CD8⁺ T cell infiltrates and PD-L1 expression predict clinical outcomes.

(A) Survival analysis of pancreatic cancer patients (TCGA database) with high (CD8⁺ T^hi) and low (CD8⁺ T^lo) infiltration of CD8⁺ T cells. The patients were split into two groups by the median of CD8⁺ T percentage. (B) Survival analysis of the available pancreatic cancer patient cohort with high (PD-L1^hi) and low (PD- L1^lo) expression of PD-L1. (C) Survival analysis of pancreatic cancer patient cohorts with indicated level of CD8⁺ T infiltrates and PD-L1 expression. The high and low level of CD8⁺ T infiltrates or PD-L1 expression were defined by their comparison to the median of CD8⁺ T percentage and the median of overall PD-L1 expression. The percentage of CD8⁺ T cells were predicted by CIBERSORT using the gene expression data from TCGA database (Details in Materials and Methods). *P = 0.039, ^#P = 0.064, & P = 0.066 (Mantel-Cox test).