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. 2016 May 9;7(28):43076–43087. doi: 10.18632/oncotarget.9246

Figure 4. EOC patients have higher level of miR-222-3p in serum-derived exosomes than healthy individuals.

Figure 4

Besides, miR-222-3p is richer in EOC-derived exosomes and can be transferred to macrophages via the exosomes. (A) MicroRNAs were abstracted in serum-derived exosomes from 6 EOC patients and from 6 healthy individuals. MiR-222-3p expression was detected by qRT-PCR. Data are shown as median ± range, n = 6 independent experiments. **p < 0.01 compared to healthy individuals group. (B) The miR-222-3p level was analyzed by qRT-PCR between EOC cells and EOC-derived exosomes. In (B), *p < 0.05 compared with the Skov3 cells and ***p < 0.001 compared with the A2780 cells. (C) Macrophages treated with PBS or Skov3-derived exosomes for 24 hours. RNA was obtained from macrophages and the expression of miR-222-3p was performed by qRT-PCR. Data are shown as mean ± SEM, n = 3 independent experiments. In (B),*p < 0.05 compared with the Skov3 cells and ***p < 0.001 compared with the A2780 cells.