Figure 3. Sulindac sulfide treatment caused a loss of the cytoskeletal architecture of the filamentous actin in MDA-MB468 A. and SUM149 B. cells.

TNBC cells were stained with phalloidin 555 for the confocal microscopy to test the effect of sulindac sulfide on the cytoskeletal architecture of the filamentous actin. The cells were stained with DAPI as a counterstain. Cells are imaged using Zeiss LSM 510 Metasystem. Successive Z-sections across cells were represented in the picture (consecutive photomicrographs) to demonstrate the effect of sulindac sulfide (photomicrographs i-p) on the organization of the filamentous actin as compared to the respective controls (photomicrographs a-h).