Table 2. Univariate analysis of ESCC patients’ survival.
| Variables | DFS | OS | ||||
|---|---|---|---|---|---|---|
| Events/patients (%) | Median DFS (mo) | P value | Events/patients (%) | Median OS (mo) | P value | |
| Age | ||||||
| ≤ 60 years | 43/76 (57) | 39 | 0.067 | 40/76 (53) | 52 | 0.020 |
| > 60 years | 56/78 (72) | 26 | 55/78 (71) | 28 | ||
| Sex | ||||||
| Male | 80/119 (67) | 26 | 0.100 | 77/119 (65) | 31 | 0.062 |
| Female | 19/35 (54) | 74 | 18/35 (51) | 84 | ||
| Tumor size | ||||||
| < 3cm | 43/69 (62) | 30 | 0.433 | 40/69 (58) | 46 | 0.272 |
| ≥ 3cm | 56/85 (66) | 26 | 55/85 (65) | 39 | ||
| Tumor depth | ||||||
| T1 | 4/12 (33) | NR | 0.002 | 1/12 (8) | NR | 0.000 |
| T2 | 23/41 (56) | 66 | 22/41 (54) | 76 | ||
| T3 | 67/95 (71) | 22 | 67/95 (71) | 29 | ||
| T4 | 5/6 (83) | 11 | 5/6 (83) | 11 | ||
| Lymph node metastasis | ||||||
| No | 43/91 (47) | 103 | 0.000 | 42/91 (46) | NR | 0.000 |
| Yes | 56/63 (89) | 18 | 53/63 (84) | 24 | ||
| TNM stage | ||||||
| I A + I B | 2/12 (17) | NR | 1/12 (8) | NR | ||
| II A + II B | 45/83 (54) | 66 | 0.000 | 42/83 (51) | 79 | 0.000 |
| III A + III B + III C | 52/59 (88) | 16 | 52/59 (88) | 23 | ||
| Histological grade | ||||||
| I | 5/14 (36) | NR | 0.071 | 4/14 (29) | NR | 0.048 |
| II | 77/114 (68) | 26 | 75/114 (66) | 35 | ||
| III | 17/26 (65) | 24 | 16/26 (62) | 28 | ||
| EIF3B expression | ||||||
| Low | 43/75 (57) | 54 | 0.022 | 41/75 (55) | 65 | 0.027 |
| High | 56/79 (71) | 24 | 54/79 (68) | 30 | ||
| Postoperative chemotherapy | ||||||
| No | 51/87 (59) | 45 | 0.092 | 48/87 (55) | 52 | 0.109 |
| Yes | 48/67 (72) | 24 | 47/67 (70) | 30 | ||
a
Bold values indicate statistical significance (p < 0.05).
Abbreviation: ESCC, Esophageal squamous cell carcinoma; EIF3B, Eukaryotic translation initiation factors; NR, not reached.