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. 2016 Jun 2;7(28):43475–43491. doi: 10.18632/oncotarget.9782

Figure 8. (−)-Oleocanthal inhibits the activation of STAT3 through regulating the expression of positive and negative regulators.

Figure 8

(A) Western blots analysis for the positive regulator of STAT3 in HepG2 and Huh-7 cells. (B) Western blots analysis for the negative regulator of STAT3 in HepG2 and Huh-7 cells. (C) HepG2 and Huh-7 cells were transfected with either SHP-1 siRNA or scrambled siRNA. After 48 h, cells were treated with 30 μM of (−)-oleocanthal for 48 h and whole cell extracts were subjected to Western blot analysis for phosphorylated STAT3. (D) Western blot analysis was performed to detect the expression of indicated protein in tumor tissue.