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(A) Athymic nude mice bearing TC32 (n = 8) or (B) TC71 (n = 5) flank xenograft tumors were treated with 50 mg/kg JQ1 twice per day. Data presented are median tumor size. Error bars represent interquartile range. (C) TC32 tumors treated with JQ1 for 3 weeks were dissected and stained using hematoxylin and eosin, or antibodies specific to Ki67 or cleaved caspase-3. Representative images (200×) are presented.
