Table 2. Genotype and allele frequencies of the TIM-3 polymorphisms among the cases and controls and the associations with breast cancer risk.

Model	Genotype	Case(560)	Control(583)	OR (95% CI)†	P-value*	Pc
rs10053538a
Codominant	GG	173 (30.9%)	221 (38.0%)	1.00 (reference)
	GT	313 (56.0%)	290 (49.8%)	1.38 (1.07-1.178)	0.014	0.042
	TT	73 (13.1%)	71 (12.2%)	1.31 (0.90-1.93)	0.162	NS
Dominant	GG	173 (30.9%)	221 (38.0%)	1.00 (reference)
	GT+TT	386 (69.1%)	361 (62.0%)	1.37 (1.07-1.75)	0.013	0.039
Recessive	GG-GT	486 (86.9%)	511 (87.8%)	1.00 (reference)
	TT	73 (13.1%)	71 (12.2%)	1.08 (0.76-1.53)	0.662	NS
Allele	G	659 (58.9%)	732 (62.9%)	1.00 (reference)
	T	459 (41.1%)	432 (37.1%)	1.18 (0.997-1.40)	0.054	NS
rs4704853b
Codominant	G/G	352 (63.1%)	402 (69.3%)	1.00 (reference)
	G/A	191 (34.2%)	166 (28.6%)	1.31 (1.02-1.69)	0.034	NS
	A/A	15(2.7%)	12 (2.1%)	1.43 (0.66-3.09)	0.364	NS
Dominant	GG	352 (63.1%)	402 (69.3%)	1.00 (reference)
	GA+AA	206 (36.9%)	178 (30.7%)	1.32 (1.03-1.69)	0.026	NS
Recessive	GG-GA	543 (97.3%)	568 (97.9%)	1.00 (reference)
	AA	15 (2.7%)	12 (2.1%)	1.31 (0.61-2.82)	0.493	NS
Allele	G	895 (80.2%)	970 (83.6%)	1.00 (reference)
	A	221 (19.8%)	190 (16.4%)	1.26 (1.02-1.56)	0.034	NS
rs1036199c
Codominant	A/A	546 (97.7%)	565 (97.2%)	1.00 (reference)
	C/A	13 (2.3%)	16 (2.8%)	0.84 (0.40-1.76)	0.646	NS
	C/C	0	0
Allele	A	1105 (98.8%)	1146 (98.6%)	1.00 (reference)
	C	13 (1.2%)	16 (1.4%)	0.84 (0.40-1.76)	0.648	NS

^*Two-sided x²test for the distributions of genotype and allele frequencies.

^†Adjusted for age and body mass index.

P_c, the Bonferroni correction of P values.

^aCase missing n = 1; control missing n = 1;

^bCase missing n = 2; control missing n = 3;

^cCase missing n = 1; control missing n = 2.