Table 4. Stratified analyses on association between TIM-3 polymorphisms and breast cancer risk.
| rs10053538 | rs4704853 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotypes | Case (N= 559) | Control (N = 582) | P* | OR (95%CI)† | Genotypes | Case (N = 558) | Control (N = 580) | P* | OR (95%CI)† |
| N (%) | N (%) | N (%) | N (%) | ||||||
| Age<49 | Age<49 | ||||||||
| GG | 89 (32.0%) | 102 (38.5%) | 0.114 | 1.00 (reference) | GG | 170 (61.8%) | 212 (70.7%) | 0.025 | 1.00 (reference) |
| GT+TT | 189 (68.0%) | 163 (61.5%) | 1.33 (0.93-1.89) | GA+AA | 105 (38.2%) | 88 (29.3%) | 1.49 (1.05-2.11) | ||
| Age≥49 | Age≥49 | ||||||||
| GG | 84 (29.9%) | 119 (37.5%) | 0.049 | 1.00 (reference) | GG | 182 (64.3%) | 190 (67.9%) | 0.374 | 1.00 (reference) |
| GT+TT | 197 (70.1%) | 198 (62.5%) | 1.41 (1.00-1.98) | GA+AA | 101 (35.7%) | 90 (32.1%) | 1.17 (0.83-1.66) | ||
*
Two-sided x2 test for the distributions of genotype frequencies.
†
Adjusted for age and age at menarche.