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. 2016 May 27;7(28):43779–43791. doi: 10.18632/oncotarget.9672

Figure 1. AKR1B10 increases adhesion, migration and invasion of breast cancer cells.

Figure 1

AKR1B10 was ectopically expressed in MCF-7 and MDA-MB-231 cells, or silenced in BT-20 cells. A. Cell adhesion to fibronectin or collagen-coated plates. B. Wound-healing of MCF-7 cells. Scale bar = 500μm. C. Transwell migration (left) and Boyden chamber invasion (right) of MCF-7 cells. D. Transwell migration (left) and Boyden chamber invasion (right) of MDA-MB-231 cells. E. Transwell migration of BT-20 cells. All data represent mean ± SD from three independent experiments. *, p<0.05 and **, p<0.01 compared to the vector control. Scram, scrambled siRNA; siR-1, AKR1B10 siRNA-1; and siR-2, AKR1B10 siRNA-2.