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. 2016 May 27;7(28):43779–43791. doi: 10.18632/oncotarget.9672

Figure 2. AKR1B10 upregulates integrin α5 and δ-catenin in breast cancer cells.

Figure 2

A. RT profiler PCR array results, showing expression of 84 cell adhesion molecules and extracellular proteins in MCF-7 cells with ectopic expression of AKR1B10. B. qRT-PCR and C. Western blot, confirming expression of interest genes in MCF-7, MDA-MB-231 and BT-20 cells. D. ERK signaling activation, showing p-Raf, p-MEK and p-ERK in MCF-7, MDA-MB-231 and BT-20 cells. E. Inhibition of integrin α5 and δ-catenin expression by MEK1/2 inhibitors, PD98059 (10μM) and U0126 (10μM), showing expression of p-ERK1/2, integrin α5, and δ-catenin in MCF-7 with ectopic AKR1B10 expression.