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. 2016 May 30;7(28):43868–43893. doi: 10.18632/oncotarget.9701

Figure 4. R-Ras promotes the migration and invasion of CRC cell lines.

Figure 4

A. Western blots showed stable over-expression of 3×Flag-R-Ras and shRNA down-regulated endogenous R-Ras; sh2 did not significantly affect endogenous R-Ras in SW480 cells. B, C. Over-expression of R-Ras enhanced the migration and invasion of SW480 and HCT116 cells in Transwell assays. D, E. Knockdown of R-Ras attenuated the migration and invasion of SW480 and HCT116 cells in Transwell assays. Significance was evaluated using the Student's t-test. *, p < 0.05, **, p < 0.01, ***, p < 0.001, ****, p < 0.0001, ns, not significant.