Table 4. Biological pathways over-represented in Stage IIIB and IIIC DEPs.
| Stage | Pathways | Up | Down | Total | |||
|---|---|---|---|---|---|---|---|
| gene count | q-value | gene count | q-value | gene count | q-value | ||
| IIIB | Fatty acid degradation - Homo sapiens (human) | NA | NSS | 6 (13.6%) | 1.20E-04 | NA | NSS |
| Metabolism | NA | NSS | 25 (1.7%) | 4.07E-04 | NA | NSS | |
| Endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides by alpha-amylase | NA | NSS | 3 (50.0%) | 5.44E-04 | NA | NSS | |
| Extracellular matrix organization | NA | NSS | 10 (3.8%) | 6.47E-04 | NA | NSS | |
| Butyrate Metabolism | NA | NSS | 3 (37.5%) | 6.47E-04 | NA | NSS | |
| Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids | NA | NSS | 3 (37.5%) | 6.47E-04 | NA | NSS | |
| Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD) | NA | NSS | 3 (37.5%) | 6.47E-04 | NA | NSS | |
| Saturated fatty acids beta-oxidation | NA | NSS | 4 (16.0%) | 7.51E-04 | NA | NSS | |
| Digestion of dietary carbohydrate | NA | NSS | 3 (33.3%) | 7.51E-04 | NA | NSS | |
| IIIC | Muscle contraction | NA | NSS | 4 (7.7%) | 1.42E-07 | 4 (7.7%) | 1.88E-05 |
| Smooth Muscle Contraction | NA | NSS | 3 (12.5%) | 1.41E-06 | 3 (12.5%) | 6.35E-05 | |
| Striated Muscle Contraction | NA | NSS | 3 (7.9%) | 3.91E-06 | 3 (7.9%) | 1.74E-04 | |
The percentages in the parentheses reflect the proportion of the over-represented genes of the input to the total gene number of corresponding pathways. NA, not available, NSS, not statistically significant.