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. 2016 Jun 11;7(28):43974–43988. doi: 10.18632/oncotarget.9949

Figure 7. The clonogenic output of MF-derived CD34+ cells after migration toward IL-1β + TNF-α + CXCL12 ± TIMP-1 is potently enhanced.

Figure 7

Panels (A and B) show the clonogenic potential of CB-derived (A; n = 6) and MF-derived CD34+ cells (B; n = 14) at baseline with or without various combinations of pro-inflammatory factors (CFU-C) and after migration toward CXCL12 alone or various combinations of pro-inflammatory factors + CXCL12 (CFU-C post-migration). After migration toward IL-1β + TNF-α + CXCL12 ± TIMP-1, the MF-derived, but not CB-derived, CD34+ cells show significantly increased clonogenic potential. Results are expressed as mean fold change of CFU-C ± SEM. (*p ≤ 0.05 vs untreated cells (A) and CXCL12 alone (B)).