Table 1. Summary of patient distribution according to disease status.
| Status of disease | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| Adjusted | |||||
| Variable | Total | Recurrence | Disease free | P value | P value |
| All cases | 149 | 68 | 77 | ||
| Age | |||||
| ≥ 60 | 74 (49.7) | 31 (43.7) | 40 (56.3) | ||
| < 60 | 75 (50.3) | 37 (50.0) | 37 (50.0) | 0.445 | 0.724 |
| Stage (%) | |||||
| lower (I,II) | 120 (80.5) | 46 (39.3) | 71 (60.7) | ||
| higher (III,IV) | 29 (19.5) | 22 (78.6) | 6 (21.4) | < 0.001 | 0.027 |
| Histologic type (%) | |||||
| squamous cell carcinoma | 139 (93.3) | 59 (43.7) | 76 (56.3) | ||
| adenocarcinoma | 5 (3.4) | 5 (100) | 0 | ||
| adenosqumous cell carcinoma | 5 (3.4) | 4 (80.0) | 1 (20.0) | 0.008 | 0.001 |
| Histologic grade (%) | |||||
| G1 | 10 (6.7) | 5 (50.0) | 5 (50.0) | ||
| G2 | 37 (24.8) | 11 (29.7) | 26 (70.3) | ||
| G3 and unknown | 102 (68.5) | 52 (53.1) | 46 (46.9) | 0.056 | 0.109 |
| Tumor size (%) | |||||
| ≥ 4 cm | 81 (54.4) | 43 (63.2) | 38 (49.4) | ||
| < 4 cm | 68 (45.6) | 25 (36.8) | 39 (50.6) | 0.098 | 0.214 |
| SKP2 expression level (SD) | 11.6 (10.6) | 17.2 (12.1) | 6.8 (6.2) | < 0.001 | < 0.001 |
| SCC level (SD) | 12.5 (26.9) | 18.6 (36.3) | 6.8 (12.7) | 0.015 | 0.042 |
| CEA level (SD) | 14.2 (57.4) | 24.7 (82.4) | 5.1 (11.7) | 0.01 | 0.027 |
| Chemotherapy (%) | 35 (23.5%) | 19 (54.3) | 16 (45.7) | 0.746 | 0.472 |
| Radiotherapy (%) | |||||
| pelvic only | 42 (28.1) | 20 (30.8) | 20 (28.6) | ||
| pelvic and brachytherapy | 97 (65.1) | 45 (69.2) | 50 (71.4) | 0.606 | 0.428 |
| dose (SD) | 5955.0 (1559.1) | 6045.2 (1702.8) | 5895.1 (1431.5) | 0.576 | 0.596 |
| Operation pattern (%) | |||||
| no hysterectomy | 105 (70.5) | 54 (81.8) | 51 (67.1) | ||
| simple hysteretomy | 6 (4.0) | 0 | 6 (25.0) | ||
| radical hysterectomy | 31 (20.8) | 12 (18.2) | 19 (7.9)) | 0.030 | 0.703 |
Abbreviations: CEA: Carcinoembryonic antigen, G1: grade 1, G2: grade 2, G3: grade 3, SCC: squamous cell carcinoma antigen, SD: standard deviation.