Table 1. Associations between three SNPs and HBV-related HCC susceptibility.
| Genotype | HCC patients | HBV persistent carriers | OR (95% CI) | P |
|---|---|---|---|---|
| (n = 1507) | (n = 1560) | |||
| N (%) | N (%) | |||
| rs3757328 | ||||
| G/G | 1038 (71.9) | 1146 (73.8) | 1.00 | |
| G/A | 362 (25.1) | 375 (24.1) | 1.07 (0.90-1.26) | |
| A/A | 43 (3.0) | 33 (2.1) | 1.44 (0.91-2.29) | |
| Dominant | 1.10 (0.93-1.29) | 0.262 | ||
| Recessive | 1.42 (0.90-2.25) | 0.134 | ||
| Additive | 1.11 (0.96-1.28) | 0.150 | ||
| rs6940552 | ||||
| G/G | 958 (64.2) | 1048 (67.5) | 1.00 | |
| G/A | 461 (30.9) | 453 (29.2) | 1.11 (0.95-1.30) | |
| A/A | 73 (4.9) | 52 (3.4) | 1.54 (1.07-2.22) | |
| Dominant | 1.16 (1.00-1.35) | 0.055 | ||
| Recessive | 1.49 (1.03-2.14) | 0.031 | ||
| Additive | 1.16 (1.03-1.32) | 0.018 | ||
| rs9261204 | ||||
| A/A | 853 (58.3) | 976 (62.9) | 1.00 | |
| G/A | 521 (35.6) | 510 (32.8) | 1.17 (1.00-1.36) | |
| G/G | 88 (6.0) | 67 (4.3) | 1.51 (1.08-2.10) | |
| Dominant | 1.21 (1.04-1.40) | 0.011 | ||
| Recessive | 1.42 (1.03-1.97) | 0.034 | ||
| Additive | 1.20 (1.06-1.35) | 0.004 | ||
| Combined genotypes (unfavorable genotypes carried) a | ||||
| 0 | 784 (55.5) | 971 (62.8) | 1.00 | |
| 1-3 | 553 (39.2) | 514 (33.3) | 1.34 (1.15-1.56) | <0.001 |
| 4-6 | 75 (5.3) | 61 (4.0) | 1.52 (1.07-2.16) | 0.019 |
Note: The logistic regression analyses were adjusted for age and gender.
a
The combined genotypes were trichotomized according to the unfavorable genotypes carried (rs3757328 AA, rs6940552 AA and rs9261204 GG were considered to be unfavorable genotypes). 0 indicates the presence of no unfavorable genotypes, 1–3 indicating the presence of 1–3 unfavorable genotypes, and 4-6 indicates the presence of 4-6 unfavorable genotypes.