Table 1. In silico analysis of the effect of TERF1 and TERF2 expression levels on overall survival and disease free survival (http://www.cbioportal.org).
| Cancer type | TERF2 | TERF1 | ||||||
|---|---|---|---|---|---|---|---|---|
| n | Overall survival | n | Disease free survival | n | Overall survival | n | Disease free survival | |
| Breast invasive carcinoma | 1092 | High expression Sup 1.5 p=0.045 | NS | NS | NS | |||
| Colon carcinoma | 374 | High expression Sup 3 p=0.008 | 330 | High expression Sup 3 p<0.001 | NS | NS | ||
| Clear cell renal cell carcinoma | NS | 435 | High expression Sup 1.1 p=0.044 | 532 | High expression p=0.016 | 434 | High expression p=0.036 | |
| Papillary renal cell carcinoma | NS | 267 | High expression Sup 2 p=0.012 | 288 | High expression p<0.001 | 267 | High expression p<0.001 | |
| Esophageal carcinoma | NS | NS | 193 | High expression, Sup 1.1 p=0.025 | NS | |||
| Head and neck squamous cell carcinoma | 517 | High expression Sup 1.1 p=0.0474 | NS | NS | NS | |||
| Lung adenocarcinoma | NS | Low expression Inf 1.5 p=0.0097 | NS | NS | ||||
| Lung squamous cell carcinoma | NS | NS | Low expression Inf 3 p=0.0065 | |||||
| Prostate adenocarcinoma | 496 | High expression Sup 1.1 p=0.002 | NS | NS | 490 | High expression Sup 3 p=0.01 | ||
| Uterine carcinoma | NS | NS | NS | 162 | High expression Sup 2.5 p=0.009 | |||
| Uveal melanoma | NS | NS | 68 | High expression Sup 2 p=0.022 | 62 | High expression Sup 2 p=0.0015 | ||
The prognostic value for overall survival and disease free survival of RNA expression levels of TERF2 and its homologue TERF1 were obtained from publicly available databases. Cancers in which overexpression of the genes is detrimental are noted as “High expression” and cancers in which a lower expression is detrimental are noted “low expression” (grey background). Head and neck squamous cell carcinoma are presented on a black background. The p-values and threshold values (Sup or Inf) are indicated together with the number of patients (n). NS: non-significant.