Table 2. Genotypes of 11 SNPs of FBW7 and its substrate genes and their association with efficacy of paclitaxel.
| Gene (Genotypes) | PD+SD(%) | PR(%) | χ2 | OR(95%CI)a | Pa |
|---|---|---|---|---|---|
| rs210940(myb) | |||||
| CC | 22(36.7) | 14(26.4) | reference | ||
| CT | 32(53.3) | 29(54.7) | 2.42 | 2.70(0.70,10.35) | 0.15 |
| TT | 6(10.0) | 10(18.9) | 0.68 | 1.07(0.42,2.74) | 0.88 |
| rs7435589(myb) | |||||
| AA | 27(45.0) | 22(42.3) | reference | ||
| AG | 28(46.7) | 24(46.2) | 0.02 | 0.89(0.37,2.12) | 0.79 |
| GG | 5(8.3) | 6(11.5) | 0.33 | 1.36(0.33,5.62) | 0.67 |
| rs1057079(mTOR) | |||||
| AA | 47(77.0) | 27(50.9) | reference | ||
| AG | 14(23.0) | 25(47.2) | 7.58 | 4.59(1.78,11.86) | <0.01 |
| GG | 0(0.0) | 1 (1.9) | 0.00 | 1.00 | |
| rs17036508(mTOR) | |||||
| TT | 54(90.0) | 45(86.5) | reference | ||
| TC | 6(10.0) | 7(13.5) | 0.32 | 0.89(0.24,3.27) | 0.86 |
| rs2536(mTOR) | |||||
| TT | 53(86.9) | 46(83.6) | reference | ||
| TC | 7(11.5) | 9(16.4) | 0.52 | 1.47(0.46,4.74) | 0.52 |
| CC | 1(1.6) | 0(0.0) | 0.00 | 1.00 | |
| rs2295080(mTOR) | |||||
| TT | 40(76.9) | 28(59.6) | reference | ||
| TG | 9(17.3) | 16(34.0) | 3.71 | 2.52(0.88,7.23) | 0.08 |
| GG | 3(5.8) | 3(6.4) | 0.18 | 1.48(0.23,9.73) | 0.68 |
| rs3124591(NOTCH1) | |||||
| TT | 48(78.7) | 43(81.1) | reference | ||
| TC | 7(11.5) | 7(13.2) | 0.62 | 0.73(0.16,3.26) | 0.68 |
| CC | 6(9.8) | 3(5.7) | 0.04 | 1.07(0.31,3.72) | 0.92 |
| rs10521(NOTCH1) | |||||
| AA | 49(80.3) | 43(78.2) | reference | ||
| AG | 10(16.4) | 11(20.0) | 0.20 | 2.25(0.18,27.78) | 0.52 |
| GG | 2(3.3) | 1(1.8) | 0.37 | 4.41(0.29,66.09) | 0.28 |
| rs9642880(c-Myc) | |||||
| GG | 26(42.6) | 30(56.6) | reference | ||
| GT | 9(14.8) | 8(15.1) | 0.22 | 0.99(0.30,3.24) | 0.99 |
| TT | 26(42.6) | 15(28.3) | 2.72 | 0.48(0.19,1.23) | 0.12 |
| rs9902941(SREBF2) | |||||
| CC | 54(88.5) | 49(92.5) | reference | ||
| CT | 6(9.8) | 4(7.5) | 0.21 | 0.88(0.18,4.29) | 0.88 |
| TT | 1(1.6) | 0(0.0) | 0.00 | 1.00 | |
| rs7685296(FBW7) | |||||
| CC | 23(37.1) | 21(41.2) | reference | ||
| CT | 6(9.7) | 8(15.7) | 0.38 | 1.06(0.28,4.06) | 0.93 |
| TT | 33(53.2) | 22(43.1) | 0.59 | 0.89(0.36,2.22) | 0.80 |
a
Adjusted for sex, age, and chemotherapy cycle